Antidepressants: What to Do When They Aren’t Working

Making sense of the choices

A fast flip via {a magazine} or a few hours in entrance of the tv will let you know that there are myriad choices when it comes to antidepressant remedy. However usually, there’s an accepted methodology by which clinicians go about discovering the particular remedy that’s best for you.

As of late, you usually begin with what’s often called an SSRI (selective serotonin reuptake inhibitor), says Dr. Saltz. It’s not identified precisely how SSRIs work, however the impact is that extra serotonin (a feel-good chemical) is circulating in your physique. SSRIs embrace medication corresponding to Prozac, Zoloft, Lexapro, and Paxil. You give the prescription six to eight weeks at a therapeutic dose, and if there isn’t any response, you possibly can attempt a distinct SSRI.

If there’s a partial response, you possibly can increase the primary SSRI with non-SSRI antidepressants corresponding to Wellbutrin or Remeron. After failing two SSRIs, explains Dr. Saltz, you possibly can then transfer to what’s often called an SNRI (which stands for serotonin and norepinephrine reuptake inhibitor), corresponding to Cymbalta and Effexor.

If the SNRI trial doesn’t work, you possibly can attempt them together. Then you can begin including “augmenting brokers” like thyroid hormone, anti-inflammatory remedies corresponding to fish oil, and even light box therapy.

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