In accordance with the National Institutes of Health, despair is most definitely the results of a mixture of organic, genetic, psychological, and social components. “We don’t actually know what causes despair,” says Victor Schwartz, MD, chief medical officer for the JED Basis, a New York Metropolis based mostly nonprofit that works to guard teen and younger grownup emotional well being. For many individuals, the episodes stem from a loss or a disturbing life change, he says. Sure medical situations akin to an underactive thyroid, most cancers, and coronary heart illness may set off despair. So too, can hormonal imbalances that occur after childbirth and through menopause. “Drugs akin to sedatives, sleeping drugs, and hypertension remedy can even precipitate despair signs,” Dr. Schwartz says.